The rivalry between two of the sport's most successful teams stretches back more than a century and is widely regarded as the most passionate in baseball.
The center-field fence will be an inviting target, just 385 feet from home plate under the preliminary configuration of stadium, which will accommodate 55,000 spectators.
The Red Sox will be the home team for both games, set for June 29 and June 30. The wall at London Stadium will be between 12 and 14 feet high between the power alleys.
"They are excited about the chance to meet new fans and showcase the game they love", he said.
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Starting at 7pm (AEST), Georgie Gardner and Karl Stefanovic will be covering the royal wedding in both London and Windsor. Markle is delighted to have her parents by her side on this important and happy occasion", the palace announced.
The NFL has played games in London every year since 2007, while the National Basketball Association has held eight regular-season games there since 2011. "So fans can expect intense competition during what will surely be a great few days in London".
Mr Khan has said he wants to make London the sporting capital of the world.
The games will mark the first time the MLB has scheduled games in Europe and the league underlined its intention to "establish a long-term footprint in the city". The Yankees opened the 2004 season with a two-game series against the Rays and the Red Sox opened the 2008 season with two games against the Oakland Athletics. There were significant challenges that had to be overcome.
"We expect an exciting and intense pair of games and appreciate the significance of representing our sport in such a meaningful way". "We look forward to welcoming Major League Baseball, teams and fans to London Stadium for the first year of what we hope to be a fruitful, long term partnership".