Ireland continued to enjoy their inaugural Test earlier in the day by dismissing dangerman Asad Shafiq as wickets kept falling at Malahide.
The 33-year-old started excellently with the ball as Pakistan's openers were put through a testing period.
Pakistan were reduced to 13-2, with Boyd Rankin and Tim Murtagh the successful bowlers, but Pakistan, sent into bat by Ireland captain William Porterfield after rain washed out Friday's opening day, recovered to 67-2 at lunch on the second day.
Boyd Rankin, who had previously taken one scalp in a lone Test appearance for England before switching allegiance to his native country, was the man to provide the breakthrough, becoming Ireland's first wicket-taker in the five-day format, producing an edge to second slip to reduce Pakistan to 13/1.
There was drama at a sun-drenched Malahide even before the wickets fell, with Pakistan debutant Imam-ul-Haq injured off the first ball of the match.
Non-striker Imam, in scrambling to complete the run, found himself sandwiched between wicket-keeper Niall O´Brien and Tyrone Kane in a heavy collision.
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Barely had the crowd's cheers subsided when Pakistan were 13-2 off the very next ball.
They didn't have to wait long for a second as Murtagh struck next ball, trapping Imam leg-before for seven on his Test debut with a ball that would have hit middle stump.
Few Pakistani fans echoed the sentiments of Akram who objected Pakistan team's move to give their customary green stripe a miss.
And when Pakistan captain Sarfraz Ahmed (20) was caught by Stirling in the slips off Thompson, the tourists were 159 for six in this stand-alone match.
Shortly after Ireland's first Test caps were awarded to 11 proud cricketers, many of whom have been instrumental in paving the way for this day, William Porterfield called correctly and without hesitation, opted to bowl.
History was made on Saturday as Ireland became the 11th nation to compete in a Test match when they stepped on the field to comete against Pakistan. However, it is the first occasion since 2000 for any team to make its test debut.