Madrid stack up as the stronger side, but with Simeone gone from the sideline after his sending-off in the semifinal, and with this one being played in France, it's easy to see the Europa League trophy ending up with either team.
With Atleti's player still celebrating their final goal of the night, Diego Simeone finally summoned his last substitute from the bench.
The Ligue 1 outfit knocked out Red Bull Salzburg to reach the competition's showpiece game.
However, should they prevail over Atletico, Marseille can go into next season boasting an astute coach getting the most out of a talented squad, financial backing and a spot in Europe's most prestigious competition.
In games played away from their home ground - the Orange Velodrome - Marseille have kept just one clean sheet in 16 games in the Europa League.
Griezmann has only won the Spanish Super Cup since joining Diego Simeone's side four years ago, featuring in the team that lost on penalties to Real Madrid in the Champions League final in 2016.
Atletico Madrid won the first ever Europa League in 2010, while the Ligue 1 outfit triumphed in the maiden Champions League campaign back in 1992-93.
His position was under threat earlier this season after heavy losses to Monaco and Rennes, but he managed to turn things around after holding a crisis meeting with the players.
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"I've played a few times against him and it's always been a good scrap", Rami said.
"This team has the character and personality needed to win", Atletico midfielder Gabi Fernandez said.
This Europa Cup Final is going to be the first meeting between these two clubs since the 2008-2009 season, where the Spanish club beat Marseille in the group stage of the Champions League.
Given the power and intensity Atletico base much of their game on, Gustavo will be integral to Marseille's resistance.
It's been a coming-of-age season for the attacker and starring in the Europa League final would be the flawless way to cap it.
Of course, this has importance beyond simply bringing the Europa League trophy to Marseille (or to any French side, for that matter) for the first time.
"Although I'm sad not to be there, I have a great feeling with German", Simeone said in his press conference on Tuesday.
Ex-West Ham star Payet added: "We know how tough it is".