Barca sealed the La Liga crown with a 4-2 win at Deportivo La Coruna last Sunday, meaning pride is all that is at stake when they face third-placed Real at the Nou Camp.
Barcelona refused to offer a repeat performance at this season's game in Madrid last December, which came in the aftermath of Zidane's side lifting the Club World Cup and this remains the key sticking point for the Frenchman. Much has been made in the build-up with the refusal of Real to give the league champions a guard of honour.
Barcelona have no injury concerns going into this game. You have to win the Champions League to play in the Club World Cup.
Whether it's Rob Palmer or Kevin Keatings, Terry Gibson or Gerry Armstrong, their voices have provided the soundtrack to some of the greatest players and teams people have ever witnessed.
Zidane says, "The most important thing is respecting what Barcelona has done, winning the league".
The match might also be the last time Madrid's record signing Gareth Bale lines up in this fixture.
"We have four games (left in the league) and we will prepare in the best way because we have to finish as high as possible". Zinedine Zidane's visitors will be eyeing revenge as well as they were blanked 3-0 in the early-season meeting at Santiago Bernabeu.
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Real Madrid takes on Barcelona in a game which many will consider a dead rubber.
"It's not up to me to decide about the guard of honour but they didn't do it".
Meanwhile Rafael Varene is an injury worry for Real Madrid, giving a chance to Jesus Vallejo to partner Sergio Ramos, while Nacho Fernandez returns after a month out with a calf injury to cover for the injured Dani Carvajal at right back.
The motivation to retain their unbeaten status after Sunday is very high - a feat they nearly managed in the 2009/10 season under Pep Guardiola.
The second El Clasico of the ongoing La Liga season will start at 8:45 pm local time, 12:15 am IST (Monday), 7:45 pm BST.
But, the Real Madrid boss has a couple of pressing concerns in defence.