The France global had been recuperating from a minor thigh problem, and his arrival is likely to provide selection headaches for the manager, given Marcus Rashford bagged a match-winning brace against Liverpool during his absence. Sevilla have no doubts but are without Sebastien Corchia and former Man City man Jeus Navas.
The 36-year-old has made only three appearances since experiencing an irregular heart rhythm in September.
The Round of 16 tie is evenly poised after the first leg in Spain, where the two sides failed to find the back of the net. But it was different at Selhurst and that propelled Jose Mourinho's side to a 2-1 win against Liverpool on Saturday. They have since gone unbeaten in eight home fixtures, keeping five clean sheets.
"Liverpool is Liverpool, it is a big match, it is a match against a direct competitor for the top four but nothing is decided yet".
Is the Manchester United vs Sevilla game online?
"We know we've got to score first and foremost to get through, but we have a lot of confidence in our ability".
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It's been one of the best spells in Manchester United's season in recent weeks. After the goalless draw with United they lost 5-2 at home against Atletico Madrid.
"Maybe they are not in the best shape, but still they win ugly", Lovren told reporters.
Los Rojiblancos have never progressed as far as the Champions League quarter-finals.
And now it all rests on the second leg at Old Trafford on Tuesday night, where the Red Devils have been traditionally good, winning 12 of their 15 league matches at the ground this season. "I would sign right now to draw 1-1 at Manchester".
Aside from this, United are pretty much with the same players from the previous game, with Phil Jones, Marcos Rojo, Daley Blind and Ander Herrera in the treatment room, whilst Zlatan Ibrahimovic's involvement has not been mentioned, despite the Swede featuring in an open-training session on Monday.